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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB2
All Species:
19.39
Human Site:
Y344
Identified Species:
47.41
UniProt:
O60825
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60825
NP_001018063.1
505
58477
Y344
Y
A
E
I
E
K
R
Y
P
E
E
F
A
L
R
Chimpanzee
Pan troglodytes
XP_001165887
467
54154
P317
T
A
E
S
L
G
V
P
Y
E
Q
W
K
I
L
Rhesus Macaque
Macaca mulatta
XP_001082732
471
54341
I323
V
P
Y
E
Q
W
K
I
L
N
E
I
D
A
G
Dog
Lupus familis
XP_537134
518
59712
Y346
Y
A
Q
I
E
K
Q
Y
P
D
E
F
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y347
Y
S
E
I
E
Q
R
Y
P
E
E
F
A
L
R
Rat
Rattus norvegicus
Q9JJH5
557
64138
Y347
Y
S
E
I
E
Q
R
Y
P
E
E
F
A
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Y407
Y
D
E
I
K
E
K
Y
P
E
E
F
A
L
R
Chicken
Gallus gallus
Q91348
470
54386
Y319
A
E
A
L
G
V
P
Y
E
Q
W
K
A
L
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
L310
A
A
Q
T
A
Q
H
L
K
P
D
F
H
T
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
A305
K
A
L
D
E
L
D
A
G
V
C
D
G
M
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
90.6
94.7
N.A.
89.9
84.1
N.A.
62
60.9
N.A.
N.A.
N.A.
N.A.
N.A.
44.5
N.A.
Protein Similarity:
100
91.6
91.4
95.9
N.A.
94
87.9
N.A.
72.8
75.6
N.A.
N.A.
N.A.
N.A.
N.A.
62.3
N.A.
P-Site Identity:
100
20
6.6
80
N.A.
86.6
86.6
N.A.
73.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
40
20
100
N.A.
100
100
N.A.
93.3
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
50
10
0
10
0
0
10
0
0
0
0
60
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
0
10
0
10
0
0
10
0
0
10
10
10
10
0
0
% D
% Glu:
0
10
50
10
50
10
0
0
10
50
60
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
60
0
0
0
% F
% Gly:
0
0
0
0
10
10
0
0
10
0
0
0
10
0
10
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
50
0
0
0
10
0
0
0
10
0
10
0
% I
% Lys:
10
0
0
0
10
20
20
0
10
0
0
10
10
0
0
% K
% Leu:
0
0
10
10
10
10
0
10
10
0
0
0
0
60
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
10
% N
% Pro:
0
10
0
0
0
0
10
10
50
10
0
0
0
0
0
% P
% Gln:
0
0
20
0
10
30
10
0
0
10
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
30
0
0
0
0
0
0
0
50
% R
% Ser:
0
20
0
10
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
10
0
0
10
0
0
0
0
0
0
0
0
0
10
10
% T
% Val:
10
0
0
0
0
10
10
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
10
10
0
0
0
% W
% Tyr:
50
0
10
0
0
0
0
60
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _